Spravato — BrainWell Psychiatry

**SPRAVATO**®️ **A New Way To Treat Depression**

*SPRAVATO®️ is the only FDA-approved ketamine-based psychedelic treatment for depression

What Is SPRAVATO®️?

SPRAVATO®️ is an FDA-approved ketamine-based nasal spray for adult patients with two forms of challenging-to-treat major depressive disorder (MDD):

adults who have had an inadequate response to two or more oral antidepressants, known as treatment resistant depression (TRD)
depressive symptoms in adults with MDD with suicidal thoughts or actions (MDSI)

***“I needed something that was going to come at the depression in a different way.”***
***-Sally***

Why Use SPRAVATO®️?

Healing effects are often felt in as little as a few hours.
In a short-term study, more patients using SPRAVATO® plus oral antidepressant demonstrated rapid and superior reduction in depressive symptoms at four weeks compared to those who received placebo plus an oral antidepressant*.
Most of the reduction in depressive symptoms was seen at 24 hours.

*Based on an overall score on a standardized rating scale

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How Does Esketamine Therapy For Depression Work?

SPRAVATO®️ is a form of a medication called esketamine, which is related to ketamine. Ketamine is often used in hospitals as an IV for pain or as an anesthetic, and it’s also used in veterinary clinics. You may have heard of ketamine being misused because it can cause intense happiness or hallucinations.

SPRAVATO®️ works differently than ketamine or traditional antidepressants. When used alongside other medications, it helps reduce depression symptoms by affecting NMDA receptors and changing chemicals in the brain related to mood.

SPRAVATO® targets a part of the brain called the glutamate system, which is important for normal brain function. Glutamate is a neurotransmitter that helps nerve cells send signals to each other. This treatment works differently from traditional medications, often providing relief faster.

How Your SPRAVATO®️ Appointment Works

Treatment Phases

After you and your healthcare provider have decided SPRAVATO® is right for you — and you understand the benefits and risks — you can start planning for treatment.
**SPRAVATO®️ treatment is divided into 3 phases:**
Phase 1 Induction (Weeks 1-4): 2 treatments per week.
Phase 2 Maintenance (Weeks 5-8): 1 treatment per week.
Phase 3 Maintenance (Weeks 9+): 1 treatment every 2 weeks.

What To Expect

Step 1: Arrive at your appointment and relax.
Step 2: Self-administer the SPRAVATO®️ spray under supervision at our approved SPRAVATO®️ center.
Step 3: Relax while someone from our team supervises (approx. 2 hrs).
Step 4: Have someone drive you home after your treatment and supervision are over.

Important Safety Information

During your SPRAVATO® treatment, you might feel lightheaded or experience a sense of euphoria. Our healthcare professionals will be there to support you throughout the session.

After the two-hour treatment, it’s normal to feel drowsy or a bit woozy. For your safety, it’s important to avoid activities like driving or using heavy machinery for the rest of the day.

Because of possible side effects affecting mental alertness and motor coordination, you won’t be able to drive, operate machinery, or do anything where you need to be completely alert until the next day. You’ll need someone to drive you home, but by the next morning, most people feel fine and can get back to their usual routine without any restrictions.

Additional safety information